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                        <td><span style="font-family:Helvetica, sans-serif; font-size:20px;font-weight:bold;">Mind & Brain News -- ScienceDaily</span></td>
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                        <td><a href="https://www.sciencedaily.com/releases/2025/11/251123085557.htm" style="font-family:Helvetica, sans-serif; letter-spacing:-1px;margin:0;padding:0 0 2px;font-weight: bold;font-size: 19px;line-height: 20px;color:#222;">A tiny enzyme may hold the key to safer pain relief</a>
                        <div style="font-family:Helvetica, sans-serif; text-align:left;color:#999;font-size:11px;font-weight:bold;line-height:15px;">Nov 23rd 2025, 11:33</div>

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                        <p>Researchers have uncovered a surprising way the brain switches pain on, revealing that neurons can release an enzyme outside the cell that activates pain signals without disrupting normal movement or sensation. This enzyme, called VLK, modifies nearby proteins in a way that intensifies pain and strengthens connections tied to learning and memory. Removing VLK in mice dramatically reduced post-surgery pain while leaving normal function untouched, offering a promising path toward safer, more targeted pain treatments.</p>
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                        <td><a href="https://www.sciencedaily.com/releases/2025/11/251123085550.htm" style="font-family:Helvetica, sans-serif; letter-spacing:-1px;margin:0;padding:0 0 2px;font-weight: bold;font-size: 19px;line-height: 20px;color:#222;">Boosting one protein helps the brain protect itself from Alzheimer’s</a>
                        <div style="font-family:Helvetica, sans-serif; text-align:left;color:#999;font-size:11px;font-weight:bold;line-height:15px;">Nov 23rd 2025, 09:23</div>

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                        <p>Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive performance. The treatment also reduced plaque levels over time. The work points toward a natural, cell-based way to slow Alzheimer’s decline.</p>
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<p><strong>Forwarded by:<br />
Michael Reeder LCPC<br />
Baltimore, MD</strong></p>

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